Main use of guanidine hydrochloride
1. Can be used as medicine, pesticide, dye and other organic synthesis intermediates. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine and 2-amino-4,6-dimethylpyrimidine. It is a sulfa drug for the manufacture of sulfadiazine, sulfamethazine and sulfamethazine. Intermediate.
2. The guanidine hydrochloride (or guanidine nitrate) is reacted with ethyl cyanoacetate to cyclize to 2,4-diamino-6-hydroxypyrimidine for the synthesis of an anti-anemic drug folic acid. It can also be used as an antistatic agent for synthetic fibers.
3. It can also be used as a protein denaturant.
4. As a strong denaturant in the extraction of total RNA from cells. The guanidine hydrochloride solution can dissolve the protein, causing destruction of the cell structure, destruction of the secondary structure of the nuclear protein, and dissociation from the nucleic acid. In addition, the RNase can be inactivated by a reducing agent such as guanidine hydrochloride.
