Summarize the adverse reactions in the treatment of anhydrous magnesium sulfate
In general, in the case of normal renal function, adverse reactions of anhydrous magnesium sulfate are generally rare. However, some studies have found some adverse reactions using magnesium sulfate, and most of these adverse reactions come from the intravenous drip route.
1 Hypotension: In a trial of intravenous magnesium sulfate in the treatment of acute exacerbation of severe asthma in children, one patient developed hypotension after using magnesium sulfate. But this does not affect the safety of intravenous magnesium sulfate.
2 respiratory failure: When magnesium sulfate is excessive, muscle weakness will occur, and there may be respiratory failure. In the study using the currently recommended magnesium sulfate dose, we did not find respiratory failure.
3 digestive tract reaction: It was found that 3 of 19 patients who received high-dose anhydrous magnesium sulfate in the vein had nausea, vomiting, pain at the infusion site, and redness, but no other serious cardiopulmonary adverse reactions were found. .
4 allergic reactions: It has been reported that two cases of urticaria appear after the use of magnesium sulfate in the mother; there are also cases of suspected anaphylactic shock caused by magnesium sulfate.
In general, anhydrous magnesium sulfate is a relatively safe drug that can be quickly rescued by calcium ions even in the presence of a drug overdose. As an antagonist of magnesium ion, calcium ion can alleviate myocardial and respiratory muscle inhibition caused by hypermagnesemia, and can be repeated if necessary.
